I'm going to give my personal opinion, biased by my own experiences, without a scientific basis or study backed up.
In my case, DMT helped me treat chronic depression "in the terminal phase", so to speak. There are two types of change, a progressive one that we all know and drastic changes. Mine was of the second type, a lot of people around me were asking me. What happened, you look like a different person, you're calm, you even speak in a different way.
After that and doing a learning tour, I started to do initiations, just as they did with me, for free. I wanted to help others just as this substance had helped me. Each person may have their own motivations for making use of psychedelics, but I differentiate between two large groups.
1) People who have tried all kinds of remedies, visited different psychologists where each one has given a different diagnosis and tried a thousand treatments and none of them have worked. And autonomously, without anyone trying to convince them, they have approached treatment with psychedelics.
2) People who want to try new things, who want to know what it's like to have "a psychedelic experience" or people who have been convinced by others that this therapy will work for them.
With the first group, who have already researched on their own how psychedelics work and have something inside them that tells them "you have to heal yourself", psychedelic therapy usually works a radical change in them. And they tend to reach high depths on their travels.
With the second group, either one or two feedings are enough to satiate their desire for new experiences, and if they are people with problems who have been convinced, they tend to have counterproductive experiences.
The most important thing is integration, as we explain to ourselves what has happened. And this is where the facilitator comes into play, the advice that is given to the person for this.
I think one of the most important benefits would be:
1) In people with depression, as was my case, a simple mild experience already shows benefits, because in a mind full of darkness, suddenly facing the light and beauty that unfolds within you, created by you, in your own mind, already acts as a lever, for change to occur.
2) We have a thing called the "default neural network," let's say, that if you're afraid of spiders, every time you see a spider and you feel scared, that neural channel is reinforced. And so with other attitudes and personality traits, all that makes us "be us" is that default neural network. When we are under the effects of a psychedelic, it is as if all the channels are available, I remember reading an article where it said that normally we have parts in the brain that work separately and under the effects of a psychedelic those kind of barriers, they disappeared. Allowing us to "think outside the box."
But it all depends on the integration capacity of each person, many do not need any external help, but there are other cases that a specialized team should help and support to make the change happen.
This study I think speaks to brain interconnectivity using DMT."Nosce te ipsum"