Chitosan and cornstarch (both OTC and natural) can enhance drug sublingual delivery. Zebbie has reported strong effects from a salvia extract mixed with cornstarch, confirmed by physicsenvy (but it is not clear if cornstarch itself or plant matter is what enhanced bioavailability). downwardsfromzero has recently reported effects for sublingual DMT on cornstarch.
It turns out that when mixed, cornstarch and chitosan can form films (see attached for details). Glycerol and acetic acid is part of the process.
These films could be tested for sublingual drug administration. Chitosan may enhance sublingual bioavailability already seen with cornstarch.
For this project we can try to:
1) Recreate chitosan/cornstarch films (e.g. starting with the attached paper). Is acetic acid really needed? Avoiding it would allow the drugs to remain in FB form.
2) Make the films in the presence of drugs so they are infused into the film (DMT, harmalas, salvinorin, mescaline, psilocybin, etc). Acetone or ethanol may be needed as a carrier in some cases.
3) Test strips sublingually for activity.
That's it for now. Cheers.